A PHASE II STUDY TO EVALUATE LY2603618 IN COMBINATION WITH GEMCITABINE IN PANCREATIC CANCER PATIENTS

The aim of this study was to determine whether checkpoint kinase 1 inihibitor (CHK1), LY2603618, and gemcitabine prolong overall survival (OS) compared to gemcitabine alone in patients with unresectable pancreatic cancer.

Patients with metastatic colorectal cancer whose disease has progressed on oxaliplatin- and irinotecan-containing regimens may benefit from EGFR-inhibiting monoclonal antibodies if they do not contain mutations in the KRAS gene (are “wild type”). It is unknown whether these antibodies, such as cetux[r]

Endostatin inhibits the pro-angiogenic action of basic fibroblast growth factor and vascular endothelial growth factor in different human cancers. This study assessed the efficacy of endostatin combined with concurrent chemoradiotherapy of non-small cell lung cancer (NSCLC).

The overall purpose of this study is to provide proof of concept for introducing the anthracycline epirubicin as an effective, biomarker-guided treatment for metastatic colorectal cancer (mCRC) patients who are refractory to treatment with oxaliplatin-based chemotherapy and have TOP2A gene amplifica[r]

21. Cheadle EJ, Selby PJ, Jackson AM: Mycobacterium bovis bacillus Calmette-Guérin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism. Immunology 2003, 108(1):79-88.22. Atkins H, Davies BR, Kirby JA, Kelly JD: Polarisation of a[r]

2 days 1, 8, and 15 plus capecitabine 1660 mg/m2 days 1–21, repeated every 28 days), or the tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR), erlotinib (standard gemcitabine plus erlotinib 100 mg daily). The survival improvement observed with both of these combi[r]

To evaluate the efficacy of cetuximab combined with modified FOLFIRI (mFOLFIRI) as a second-line treatment in metastatic gastric cancer patients and to identify potential biomarkers of clinical outcomes

This phase II bridging study assessed the safety and efficacy of nab-paclitaxel/gemcitabine (Metastatic Pancreatic Adenocarcinoma Clinical Trial [MPACT] regimen) in Chinese patients with metastatic pancreatic cancer (MPC).

S-1 plus oxaliplatin(SOX) has been demonstrated to be effective and well tolerated for patients with metastatic gastric cancer. We conducted this phase II study to evaluate the feasibility of SOX as adjuvant chemotherapy for gastric cancer after curative resection

Biliary tract cancer (BTC) is a dismal disease, even after curative intent surgery. We conducted this prospective, non-randomized phase II study to evaluate the feasibility and efficacy of cisplatin and gemcitabine as adjuvant treatment in patients with resected BTC.

strong oxidative stress and aging induce both subtle andsevere alterations in proteasome biology [73].The proteasome is involved in multiple cellular path-ways, regulating cell proliferation, cell death, neuro-pathological events and drug resistance in humantumour cells. Therefo[r]

The purpose of this observational study was to evaluate feasibility, efficacy results and toxicity observations of capecitabine in routine first line treatment of patients with metastatic colorectal cancer, with particular regard of elderly patients (>75 years of age).

Genes associated with hereditary breast and ovarian cancer (HBOC) and colorectal cancer (CRC) predisposition have been shown to play a role in pancreatic cancer susceptibility.

To evaluate the plasma testosterone level in male patients with chronic kidney disease stage III - V, pre-dialysis. Subjects and methods: A cross-sectional study with a study group of 118 chronic kidney disease patients, pre-dialysis.

The role of post-mastectomy radiotherapy (PMRT) in the treatment of patients with T1–2N1 breast cancer is controversial. This study’s purpose was to evaluate the risk of recurrence of T1–2N1 breast cancer and the efficacy of PMRT in low-, medium- and high-risk groups of patients.

Several studies have shown, that circulating tumor cells (CTC) have a negative prognostic value in colorectal cancer patients. Aim of this study was to evaluate the role of CTC in specifically rectal cancer patients regarding the influence on overall survival and to elucidate the impact of CTC in pr[r]

Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to chemotherapy, tumor recurrence, and metastasis. The molecular mechanisms of chemoresistance in LRCC remain to-date incompletely understood.

has, for example, led to the development of multi-marker diagnostic [5] and prognostic [6,7] assays thatare nearing clin ical application. More recently , thisapproach has led to the discovery that PHIP, involved inthe IGF pathway, represents a positive prognostic factorfor mela[r]

Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. In this in vitro study, we evaluated the antitumor efficacy of cisplatin in combination with Bithionol (BT) against a panel of ovarian cancer cell lines[r]

has, for example, led to the development of multi-marker diagnostic [5] and prognostic [6,7] assays thatare nearing clin ical application. More recently , thisapproach has led to the discovery that PHIP, involved inthe IGF pathway, represents a positive prognostic factorfor mela[r]