LGR5 EXPRESSION IS ASSOCIATED WITH PROGNOSIS IN POORLY DIFFERENTIATED GASTRIC ADENOCARCINOMA - TRƯỜNG ĐẠI HỌC HỒNG ĐỨC

SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC.

Tumour-associated lymphocytes (TALs) have been linked with good prognosis in several solid tumours. This study aimed to evaluate the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma.

Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with clinicopathological parameters and prognosis in oral squamous cell carcinoma (OSCC).

Luan-Jing Zhang 1 † , Ke-Bing Wang 1,2 † , Long-shan Liu 1 , Lian-zhou Chen 1 , Bao-Gang Peng 3 , Li-Jian Liang 3 , Zhi Li 4 , Ling Xue 4 , Wen Li 1* and Jing-Tang Xia 2*
Abstract
Background: Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; h[r]

Mucinous adenocarcinoma (MAC) is a distinct type of colorectal cancer (CRC) associated with poor response to treatment and poorer prognosis. MAC is diagnosed by WHO definition when the extracellular mucin is more than 50% of the lesion.

It is generally accepted that microRNA-20a (miR-20a) is aberrantly expressed in gastrointestinal cancer (GIC), and may be associated with the prognosis of GIC patients. Nevertheless, the clinical prognostic value of miR20a expression in GIC remains controversial.

Talin-1 is a cytoskeletal protein that plays an important role in tumourgenesis, migration and metastasis in several malignant tumors. The aim of this study was to evaluate the expression and prognostic value of Talin-1 in nasopharyngeal carcinoma (NPC).

Helicobacter pylori is an important pathogenic factor in gastric carcinogenesis. Angiogenesis (i.e., the growth of new blood vessels) is closely associated with the incidence and development of gastric cancer. Our previous study found that COX-2 stimulates gastric cancer cells to induce expression o[r]

h repeat-containing G-protein-coupled receptor 5 (LGR5) is a promising intestinal stem cell and carcinoma stem cell marker. We examined the relationship between mismatch repair (MMR) protein deficiency and LGR5 expression in poorly differentiated (PD) colorectal carcinoma (CRC).

Neuroblastoma patients with MYCN amplification are associated with poor prognosis. However, the prognostic relevance of MYCN associated genes in neuroblastoma is unclear.

In 160 cases, patients’ ages ≥ 48 years to <48 years was 97:63. The hematoxylin and eosin-stained slides of the different biopsies were reviewed by two experienced pa- thologists and one appropriate paraffin block was se- lected for this study. Histopathological grades were made using the[r]

RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified.

The efficacy and safety of preoperative chemoradiation therapy (CRT) for advanced esophago-gastric adenocarcinoma are still in question, and the prognosis of these patients is poor. Methods: We systematically searched electronic databases from January 1990 to July 2014.

Figure 4. Schematic for urea breath test testing [185]
The 14 C UBT is inexpensive and easy to perform since it needs only a scintillation counter to measure radioactivity of breath sample. The sensitivity and specificity of the test are 92.3-97% and 85.5-90%, respectively [188, 189] .[r]

In this work, we demonstrated that either STK33-RNAi or PD98059 remarkably reduced cell viability of Fadu cells, implying that STK33-RNAi was able to inhibit the growth of Fadu cells in vitro . Meanwhile, the exposure of Fadu cells to STK33-RNAi led to cell destruction with spec[r]

Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer therapeutics.

One of the biggest limitations in studying new epige- netic therapies in a given disease is the lack of mecha- nistic understanding to distinguish which molecular events are drivers and passengers in tumorigenesis. In the meantime, translational progress requires p[r]

Many studies support the hypothesis that specific microRNA (miRNA) expression in various human cancers including hepatocarcinogenesis is closely associated with diagnosis and prognosis. In hepatocellular carcinoma (HCC), malignancy level is related to the degree of histological differentiation.

There is a paucity of data on familial risk of developing esophageal adenocarcinoma, gastric cardia adenocarcinoma and distal gastric adenocarcinoma from population-based studies. This study provides evidence that family history of hiatal hernia is a risk factor for esophageal adenocarcinoma and gas[r]

Aldehyde dehydrogenases (ALDHs) are a group of proteins that share highly conserved sequences essential for function. Each subunit contains a catalytic domain, a
cofactor binding domain, and a bridging domain. Each subtype’s catalytic pocket has a specificity for a parti- cular substrate [7]. The[r]