BÁO CÁO Y HỌC: " DIFFERENCES IN ALLERGEN-INDUCED T CELL ACTIVATION BETWEEN ALLERGIC ASTHMA AND RHINITIS: ROLE OF CD28, ICOS AND CTLA-4" POTX

concentration expressed as a relative fold change compared to control HepG2 cells (not exposed to ethanol). White and black bars represent 6 and 24 hr exposure times, respectively. Results are the mean of six different experiments (n=6). Error bars represents standard deviations. Significance is sho[r]

relatively similar pattern to that found in the untreated control cells. The pairwise comparison analysis demonstrated four significantly up-regulated (COBRA1, ITGB4, STAU2, and HMGN3) genes and one down-regulated (ANK3) gene. All these genes exert their function on transcriptional and translational[r]

proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood. 1999; 93: 1809-1816. 23. Hamajima N, Matsuo K, Saito T, et al. Interleukin 1 polymorphisms, lifestyle factors, and Helicobacter pylori infection. Jpn J Cancer Res. 2001; 92: 383-[r]

date the mechanism of this network. However, a poor correlation between mRNA and protein abundance has also been reported [9]. Furthermore, a single gene can encode for more than one mRNA species through differential splicing, and proteins can undergo as many as 200 posttranslational modifications.[r]

hepatitis C virus to CD81. Science 1998; 282: 938-41. 25. Agnello V, Abel G, Elfahal M, Knight GB and Zhang QX. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci U S A 1999; 96: 12766-71. 26. Scarselli E, Ansuini H, Cerino R, Roccas[r]

may cause adverse effects that need a discontinuous use, in about 20% of patients. [49] Oxipurinol inhibits xanthine oxidase too and is an alternative to allopuri-nol, but an allergy to allopurinol is a contraindication to its use, owing to cross-allergies between them. [50] Parental administration,[r]

protein degradation. Metabolism 1997; 46: 673-9. 25. Baulieu EE, Robel P. Dehydroepiandrosterone (DHEA) and de-hydroepiandrosterone sulfate (DHEAS) as neuroactive neuros-teroids. Proc. Natl Acad Sci USA. 1998; 95: 4089-91. 26. Yorek MA, Coppey LJ, Gellett JS, et al. Effect of treatment of diabetic r[r]

been identified to date [2], but the real number is probably higher, since less than 50% of known and putative genes have an identified function. The asso-ciation between defects in DNA repair and cancer was established by Cleaver in 1968 [3], who showed that xeroderma pigmentosum (XP) is caused by[r]

Corresponding address: Jin Zhong Li, D.V.M. Ph.D., Department of Neurological Surgery, University of Virginia Health System, P. O. Box 800212, Charlottesville, Virginia 22908, USA Received: 2006.05.02; Accepted: 2006.05.31; Published: 2006.06.01 Osteogenic potentials of some recombinant human bone m[r]

accumulation is limited. However, putative mechanisms exist where the presence of a particular viral component leads to lipid accumulation within the hepatocyte. HCV core protein has been studied at length in both cell cultures and in transgenic mice. Intracellular lipid buildup seems to occur when[r]

investigate the effect of an activated PPARδ. In an obese state the activities of numerous interacting genes are altered which may influence the effect of PPARδ on metabolism. In our data and in the study by Skogsberg et al., the effect of the C allele on lipid levels increased if over-weight indivi[r]

Trepo C, et al. Analysis of HCV co-infection with occult hepatitis B virus in patients undergoing IFN therapy. J Clin Virol 2005;33:150-157. 49. Villa E, Grottola A, Buttafoco P, Colantoni A, Bagni A, Ferretti I, Cremonini C, et al. High doses of alpha-interferon are required in chronic hepatitis du[r]

As no environmental factor identified to date will reduce blood pressure levels to 110/70 mm Hg -- the average found in the Kuna, even those over 65 years of age -- identification of potential environmental factors was of considerable interest. We learned that Kuna still residing in their indigenous[r]

Canada and 9149 subjects were included (4266 men and 4883 women). A high BMI was found to be a significant predictor of asthma incidence in women but not in men. The authors speculate that female sex hormones may play an important role in the aetiology of asthma and that these hormones are influence[r]

Figure 2. A model showing how Ku70 or ligase IV deficiency represses lethality caused by DSB inducing agents in PARP-1-/- DT40 cells. (A) Treatment of DSB inducing agents in PARP-1-/- DT40 cells decreases ability of HR (HR*) and causes DSBs. (B) Ku-70 protein competes with HR machinery and binds to[r]

Chronic hepatitis C is the most common cause of chronic liver disease and cirrhosis, and the most common indication for liver transplantation in the United States (U.S.), Australia, and most of Europe.[1-3] Approximately 170 million people are affected with HCV worldwide, comprising ~3% of the globa[r]

FBW7, FBXW7) has recently emerged as a potent new potential tumor suppressor gene [1, 2]. The highly conserved protein consists of an NH2 terminal F-box and seven WD40 repeats in the COOH terminal region and acts as an adaptor protein providing substrate specificity for SCF (Skp–Cullin–F-box) ubiqui[r]

Kevin Robertson5, Robert Paul6, Cecilia Shikuma1, Victor Valcour1 1. Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA; 2. Armed Forces Research Inst. Med. Sciences, Bangkok, Thailand; 3. Phramongkutklao Hosp., Bangkok, Thailand; 4. Royal Thai Army Med. Dept., Ban[r]

severe with occasional lymphoid aggregates (Figure 2) [4,11]. Actively proliferating bile ductiles are often seen. Risk factors for severe recurrent HCV include advanced donor age, HCV genotype 1, high HCV RNA levels before and after transplant, early histological recurrence of HCV, concomitant cyto[r]

3. Department of Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daikominami, Higashi-ku, Na-goya, 461-8673 Japan Correspondence to: Simon Itou, Department of Preventive Medicine / Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Ts[r]