BÁO CÁO KHOA HỌC: "ISOLATION OF SPECIFIC AND BIOLOGICALLY ACTIVE PEPTIDES THAT BIND CELLS FROM PATIENTS WITH ACUTE MYELOID LEUKEMIA (AML)" DOC

proliferation and/or differentiation in the target patient cells. Two of the peptides, HP-A2 and HP-G7, appeared to have a novel mechanism of inducing differentiation since they did not cause G1arrest in cycling cells even as the expression of[r]

* Corresponding author AbstractBackground: When comparing myelogenous blasts from bone marrow and peripheral blood,immunophenotyping usually show a strong correlation of expression of surface antigens. However,it remains to be determined, whether this correlation also exi[r]

, 2 mM DTT, and pro-tease inhibitors [1 mM phenylmethylsulfonyl fluoride(PMSF), 1 mg/mL l eupeptin, and 1 m g/mL antipain].Aliquots of the homogenates (40 μg total protein/lane)were loaded on SDS-polyacrylamide gels at the appro-priate concentrations. Electrophoresis was perform[r]

3. Darra E, Abdel-Azeim S, Manara A, Shoji K, Marechal JD, Mariotto S,Cavalieri E, Perbellini L, Pizza C, Perahia D, Crimi M, Suzuki H: Insight intothe apoptosis-inducing action of α-bisabolol towards malignant tumorcells: Involvement of lipid rafts and Bid. Arch Biochem Biophys[r]

protective coatings inside metal food containers, and ascomposite and sealant in dentistry. Exposure to BPA isthought to result primarily from ingestion of food con-taining BPA [6,7]. BPA is of concern to environmentalpublic health because of its toxicity. A[r]

IV. AML not otherwise categorized AML minimally differentiated AML without maturation AML with maturation Acute myelomonocytic leukemia Acute monoblastic and monocytic leukemia Acute erythroid leukemia Acute megakaryoblastic leukemia<[r]

However, patient's condition worsened rapidly. Threeweeks after the diagnosis of T-LPD, the patient died ofmultiple organ failure with pneumonia and sepsis. Anautopsy revealed the presence of leukemic cell infiltrationinto multiple organs: the BM, liver, spleen, lymph nod[r]

Myeloid leukemia may be classified as Acute Myeloid Leukemia (AML) or Chronic Myeloid Leukemia (CML) based on its rate of progression. Administration of drugs is the best modality to treat myeloid leukemia, Imatinib mesylate (IM) and cytarabine (cyt) for CML and AML respectively. However, these drug[r]

Chapter 104. Acute and Chronic Myeloid Leukemia (Part 3) Immunophenotype and Relevance to the WHO Classification The immunophenotype of human leukemia cells can be studied by multiparameter flow cytometry after the cells are labeled [r]

cal functions remain to be elucidated for the other fusion partners. Thisminireview tries to sum up some of the available data and mechanismsidentified in leukemic stem and leukemic tumor cells and link this informa-tion with the known functions of mix[r]

includes different biologically distinct groups based on immunophenotype, clinical features, and cytogenetic and molecular abnormalities in addition to morphology. In contrast to the previously used French-American-British (FAB) schema, the WHO classification places limited reli[r]

Excess bleeding or bleeding from unusual sites (DIC, thrombocytopenia) Fevers or recurrent infections (granulocytopenia) Headache, vision changes, nonfocal neurologic abnormalities (CNS leukemia or bleed) Early satiety (splenomegaly) Family history of AML (Fanconi, Bloom, or Kos[r]

with 11q23 chromosomal abnormalities. Hematologic Findings Anemia is usually present at diagnosis and can be severe. The degree varies considerably, irrespective of other hematologic findings, splenomegaly, or duration of symptoms. The anemia is usually normocytic normoch[r]

(Chap. 99). Other Nonmalignant Diseases Theoretically, hematopoietic cell transplantation should be able to cure any disease that results from an inborn error of the lymphohematopoietic system. Transplantation has been used successfully to treat congenital disorders of wh[r]

suicide gene approach was used to demonstrate a potentanti-tumor effect of eliminating Tie+ monocytes [23].While representing important proofs of concept, thesetechniques obviously cannot be applied to humans.Other studies have utilized immunotherapeuticapproaches; antibody therapeutic[r]

Redman BG, Margolin KA, Merchan JR, Wilding G, Ginsberg MS, Bacik J,Kim ST, Baum CM, Michaelson MD: Sunitinib in patients with metastaticrenal cell carcinoma. Jama 2006, 295:2516-2524.8. Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O,Oudard S, Negrier S, Szczylik C[r]

A noncontrast head CT is done routinely on all patients presenting to the emergency department with acute stroke. This CT scan will be reviewed for evidence of ICH or other exclusionary pathology prior to randomization. As part of the normal standard of care[r]

not generally recommended for routine microbiology laboratories except in life-threatening organ involve-ment, and in case of treatment failure and relapse [21]. Another problem with such testing is the lack of standardization. Methods for MIC determination are des[r]

Chapter 105. Malignancies of Lymphoid Cells (Part 15) B Cell Chronic Lymphoid Leukemia/Small Lymphocytic Lymphoma: Treatment Patients whose presentation is typical B cell CLL with no manifestations of the disease other than bone marrow involvement and