CHAPTER 059 BLEEDING AND THROMBOSIS PART 1

Chapter 059. Bleeding and Thrombosis (Part 1) Harrison's Internal Medicine > Chapter 59. Bleeding and Thrombosis Bleeding and Thrombosis: Introduction The human hemostatic system provides a natural balance between procoagulant and anticoagulant forces. The procoagulant forces i[r]

Chapter 059. Bleeding and Thrombosis (Part 4) Approach to the Patient: Bleeding and Thrombosis Clinical Presentation Disorders of hemostasis may be either inherited or acquired. A detailed personal and family history is key in determining the chronicity of symptoms and the likelihood of the[r]

Chapter 059. Bleeding and Thrombosis (Part 5) Epistaxis is a common symptom, particularly in children and in dry climates, and may not reflect an underlying bleeding disorder. However, it is the most common symptom in hereditary hemorrhagic telangiectasia and in boys with vWD. Clues that epi[r]

Chapter 059. Bleeding and Thrombosis (Part 3) Sites of action of the four major physiologic antithrombotic pathways: antithrombin (AT); protein C/S (PC/PS); tissue factor pathway inhibitor (TFPI); and the fibrinolytic system, consisting of plasminogen, plasminogen activator (PA), and plasmin[r]

Chapter 059. Bleeding and Thrombosis (Part 2) Coagulation is initiated by tissue factor (TF) exposure, which, with factor (F)VIIa, activates FIX and FX, which in turn, with FVIII and FV as cofactors, respectively, results in thrombin formation and subsequent conversion of fibrinogen to fibri[r]

Chapter 059. Bleeding and Thrombosis (Part 6) Underlying Systemic Diseases that Cause or Exacerbate a Bleeding Tendency Acquired bleeding disorders are commonly secondary to, or associated with, systemic disease. The clinical evaluation of a patient with a bleeding tendency must therefore in[r]

Chapter 059. Bleeding and Thrombosis (Part 7) The most important point in a history related to venous thrombosis is whether the thrombotic event was idiopathic (meaning there was no clear precipitating factor) or was a precipitated event. In patients without underlying malignancy, having an[r]

Chapter 059. Bleeding and Thrombosis (Part 8) Screening Assays The most commonly used screening tests are the PT, aPTT, and platelet count. The PT assesses the factors I (fibrinogen), II (prothrombin), V, VII and X (Fig. 59-6). The PT measures the time for clot formation of the citrated plas[r]

Chapter 059. Bleeding and Thrombosis (Part 9) Mixing Studies Mixing studies are used to evaluate a prolonged aPTT or, less commonly PT, to distinguish between a factor deficiency and an inhibitor. In this assay, normal plasma and patient plasma are mixed in a 50:50 ratio, and the aPTT or PT[r]

33 Internal Control Over Financial Reporting 33 Compliance and Other Matters 34 This is trial versionwww.adultpdf.comDECEMBER 2010 REPORT NO. 2011-059 2 As discussed in note 2 to the financial statements, the Regional Campus discontinued reporting bonds and revenue certificates payable for[r]

10 DEBT ADMINISTRATION The Regional Campus’s beginning net assets was increased by $0.5 million to correct an error in reporting bonds and revenue certificates payable for State University System Capital Improvement Trust Fund Revenue Bonds. In prior fiscal years the liability for these bonds was re[r]

No. 9, Reporting Cash Flows for Proprietary and Nonexpendable Trust Funds and Governmental Entities That Use Proprietary Fund Accounting. This is trial versionwww.adultpdf.comDECEMBER 2010 REPORT NO. 2011-059 UNIVERSITY OF SOUTH FLORIDA POLYTECHNIC A REGIONAL CAMPUS OF THE UNIVERSITY OF SOUT[r]

contributions for the fiscal years ended June 30, 2008, June 30, 2009, and June 30, 2010, totaled $248,784, $249,213, and $311,546, respectively, which were equal to the required contributions for each fiscal year. As provided in Section 121.4501, Florida Statutes, eligible FRS members may elect to[r]

33 Internal Control Over Financial Reporting 33 Compliance and Other Matters 34 This is trial versionwww.adultpdf.comDECEMBER 2010 REPORT NO. 2011-059 2 As discussed in note 2 to the financial statements, the Regional Campus discontinued reporting bonds and revenue certificates payable for[r]

10 DEBT ADMINISTRATION The Regional Campus’s beginning net assets was increased by $0.5 million to correct an error in reporting bonds and revenue certificates payable for State University System Capital Improvement Trust Fund Revenue Bonds. In prior fiscal years the liability for these bonds was re[r]

No. 9, Reporting Cash Flows for Proprietary and Nonexpendable Trust Funds and Governmental Entities That Use Proprietary Fund Accounting. This is trial versionwww.adultpdf.comDECEMBER 2010 REPORT NO. 2011-059 UNIVERSITY OF SOUTH FLORIDA POLYTECHNIC A REGIONAL CAMPUS OF THE UNIVERSITY OF SOUT[r]

contributions for the fiscal years ended June 30, 2008, June 30, 2009, and June 30, 2010, totaled $248,784, $249,213, and $311,546, respectively, which were equal to the required contributions for each fiscal year. As provided in Section 121.4501, Florida Statutes, eligible FRS members may elect to[r]

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