BÁO CÁO Y HỌC: "EQUIPOISE, DESIGN BIAS AND RANDOMIZED CONTROLLED TRIALS: THE ELUSIVE ETHICS OF NEW DRUGS – A COMMENT" PPTX

there is data suggesting that obesity accelerating fibrosis. 6. Research Direction Although significant advances in therapeutic options have improved the outcome in the management of HCV infection, many challenges remain ahead. The proportion of chronic HCV not responding to the available drugs is f[r]

recipients. Clinical Gastroenterol Hepatol. 2005; 10:S125-31 19. Lee W, Dieterich D. Challenges in the management of HIV and hepatitis C virus infection. Drugs. 2004;64(7):693-700 20. Bica I, McGovern B, Dhar R, et al. Increasing mortality due to end-stage liver disease in patients with Human Immuno[r]

Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the 1045 patients enrolled into the initial “lead-in” phase had biopsy proven cirrhosis. Preliminary results show t[r]

among natural weight loss supplements. Theoretically, they may promote weight loss by interfering with the breakdown of complex carbohydrates thereby reducing, or at least slowing, the digestive availability of carbo-hydrate-derived calories and/or by providing resistant starches to the lower gastro[r]

Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the 1045 patients enrolled into the initial “lead-in” phase had biopsy proven cirrhosis. Preliminary results show t[r]

subjects walked briskly for 20 minutes at 45-80% heart rate (HR) reserve (to achieve an intensity of 11-14 of Rating of Perceived Exertion Scale), more than 5 days a week. They also performed a 30 minute resistance training (3 times per week) consisting of a 5-minute warm-up and[r]

Int. J. Med. Sci. 2006, 3 117International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(4):117-123 ©2006 Ivyspring International Publisher. All rights reserved Review PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? Jos[r]

unstable chronic condition including dementia, alcoholism, dialysis, retinal hemorrhage or detachment, or current participation in resistance training. Written informed consent was given in Spanish, as approved by the Institutional Review Board at Tufts University-New England Medical Center. Interve[r]

tions, permitting to continue chemotherapy. [54,55] The use of rasburicase is a good option, sometimes better than use of allopurinol in patients with severe acute hyperuricemia. Allopurinol is a structural analogous of hypoxanthine, inhibitor of xanthine oxi-dase, the last enzyme invo[r]

pattern. It is possible that participants who have been diagnosed with a chronic disease may have changed their diet. To address this concern we adjusted for the presence of chronic disease (CHD, cancer, and stroke) and hypertension throughout the analyses. We also repeated the analyses exclu[r]

2005; 352(20):2049–2060. 15. Sarnak MJ, Katz R, Stehman-Breen CO, et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 2005; 142(7):497–505. 16. Mooradian AD. Digitalis. An update of clinical pharmacokinetics, therapeutic monitoring techniques an[r]

current study may bias the results towards unity as well. Because of our reliance on dispensing information in the record linkage study, we do not know whether the women in the study actually took the drugs. However, the fact that patients are required to pay partially for the costs themselves is li[r]

hypothesis and at the surveillance process we study a large number of “exposures” (in this case drugs) and many outcomes (in this case different types of congenital malformations) it is to be expected that a number of apparently significant associations will occur. In this situation th[r]

FBW7, FBXW7) has recently emerged as a potent new potential tumor suppressor gene [1, 2]. The highly conserved protein consists of an NH2 terminal F-box and seven WD40 repeats in the COOH terminal region and acts as an adaptor protein providing substrate specificity for SCF (Skp–Cullin–F-box)[r]

the intracellular pool to the plasma membrane [5, 6]. However, sustained insulin deficiency leads to a decreased number of GLUT4 transporters, resulting in impaired responsiveness of glucose transport to both insulin and exercise [4, 7]. People with type 2 diabetes have been shown to have def[r]

Trepo C, et al. Analysis of HCV co-infection with occult hepatitis B virus in patients undergoing IFN therapy. J Clin Virol 2005;33:150-157. 49. Villa E, Grottola A, Buttafoco P, Colantoni A, Bagni A, Ferretti I, Cremonini C, et al. High doses of alpha-interferon are required in[r]

measurement of the oxygen equilibrium curves of Hb J Meerut showed a slightly increased oxygen affinity [4]. In our case, the slight increase in the oxygen affinity of Hb J Meerut relative to that of the normal control has been shown by the low p50 values in arterial whole blood. In Hb J Meer[r]

Int. J. Med. Sci. 2006, 3 79International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):79-83 ©2006 Ivyspring International Publisher. All rights reserved Review Management of HCV Infection and Liver Transplantation Thomas D. Schiano, and Paul Martin Adult Liver Transplantation[r]

Int. J. Med. Sci. 2006, 3 79International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):79-83 ©2006 Ivyspring International Publisher. All rights reserved Review Management of HCV Infection and Liver Transplantation Thomas D. Schiano, and Paul Martin Adult Liver Transplantation[r]

outstandingly favorable against H. pylori infections for not interfering the normal bacterial flora in the intestine of humans. Moreover, it should also be advantageous that the compounds of Rice-fluid failed to affect the survival of S. aureus, S. epidermidis, and P. aeruginosa, demonstrating that[r]