Tumor recurrence and metastasis occur at a high rate in patients with colon cancer. Identification of effective strategies for the treatment of colon cancer is critical. Recently, poly (lactic-co-glycolic acid) (PLGA) has been shown to have potential as a broad therapeutic drug delivery system.
Best Practice Guidelines Program would like to acknowledge the followingindividuals and organizations for their contributions to the developmentof the self-learning package Falls Prevention: Building the Foundations ofPatient Safety. A Self-Learning Package.Mary Townend and Char[r]
Two New Drugs for Skin and Skin Structure Infections The FDA has approved two new drugs for treatment of adults with acute bacterial skin and skin structure infections caused by susceptible gram-positive bacteria. Dalbavancin... Sucroferric Oxyhydroxide (Velphoro) for Hyperphosphatemia Most patie[r]
This is a study of improving pronunciation of English with respect to linking and assimilation for Êđê learners. This study attempts to achieve three objectives that are (i) identifying the potential causes of Êđê learners’ errors in producing English sounds; (ii) identifying the problems of English[r]
Colon adenocarcinoma (COAD) is one of the most lethal cancers. It is particularly important to accurately predict prognosis and to provide individualized treatment. Several lines of evidence suggest that genetic factors and clinicopathological characteristics are related to cancer onset and progress[r]
Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes used as third- or later-line treatment for AGC refractory to fluoropyrimidine and taxanes.
In Brief: Generic Celecoxib The FDA has authorized two manufacturers (Teva, Mylan) to market generic formulations of celecoxib (Celebrex – Pfizer), the only COX-2 selective inhibitor remaining on the US market.... Extended-Release Oxycodone and Acetaminophen (Xartemis XR) The FDA has approved a f[r]
Mucinous adenocarcinoma (MAC) is a distinct type of colorectal cancer (CRC) associated with poor response to treatment and poorer prognosis. MAC is diagnosed by WHO definition when the extracellular mucin is more than 50% of the lesion.
Present study aims to evaluate the amleorative potential of Mentha piperita (MP) against arsenic trioxide (ATO) in freshwater fish Channa punctatus (Bloch). Fish were divided into six groups. G1 served as control. Fish of G2 and G3 were treated with 96 h-LC50/10 of ATO and 8 mg/l of MP, respectively[r]
chemotherapeutic drug is independent of freeradical action; antioxidants help maintain thehealth of normal tissues and protect them fromthe toxic effects of free radical–producingcytokines that circulate in cancer patients andincrease with the severity of[r]
Neoadjuvant therapy plus oesophagectomy has been accepted as the standard treatment for patients with potentially curable locally advanced oesophageal cancer. No completed randomized controlled trial (RCT) has directly compared neoadjuvant chemotherapy and neoadjuvant chemoradiation in patients with[r]
Durlaza - A 24-Hour Extended-Release Aspirin The FDA has approved Durlaza (New Haven Pharmaceuticals), a 24-hour extended-release (ER) aspirin formulation available only by prescription, for secondary prevention of myocardial... Fluad - An Adjuvanted Seasonal Influenza Vaccine for Older Adults Th[r]
For novel cancer treatments, effectiveness in clinical practice is not always aligned with clinical efficacy results. As such it is important to understand a treatment’s real-world effectiveness. We examined real-world population-based comparative effectiveness of second-line ipilimumab versus non-i[r]
This book gives an introduction to R to build up graphing, simulating and computing skills to enable one to see theoretical and statistical models in economics in a unified way. The great advantage of R is that it is free, extremely flexible and extensible. The book addresses the specific needs of e[r]
Edoxaban (Savaysa) - The Fourth New Oral Anticoagulant The FDA has approved edoxaban (Savaysa – Daiichi Sankyo), a once-daily, oral, direct factor Xa inhibitor, for treatment of venous thromoboembolism (VTE) and for prevention of stroke and... Secukinumab (Cosentyx) for Psoriasis Secukinumab (Cos[r]
Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death and upregulation of 78-kDa glucose-regulated protein (GRP78).
Bezlotoxumab (Zinplava) for Prevention of Recurrent Clostridium difficile Infection The FDA has approved the fully human monoclonal antibody bezlotoxumab (Zinplava – Merck) for use with antibacterial drug treatment to reduce recurrence of Clostridium difficile... Nusinersen (Spinraza) for Spinal M[r]
A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying chemotherapy resistance will improve treatment efficacy through genetic testing and nov[r]